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To administer intravenous drugs through a central line, begin by cleaning your hands with alcohol hand rub until dry. Identify the patient and explain the procedure, ensuring no contraindications exist. Expose the line for easy access and wear an apron and non-sterile gloves. Open swab packages without touching the swab spaces and thoroughly scrub the ports with a chlorhexidine wipe for 15 seconds. Use the needle's hub for access without cap removal, which prevents air from entering the line during syringe changes. Place the core stops under the line port on a sterile area and obtain an empty syringe for use.