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and if youamp;#39;ve ever been blackout drunk and certainly if youamp;#39;ve been blackout drunk more than a few times you should be quite concerned and as we talk more about the more chronic effects and long-lasting effects of alcohol consumption a little bit later in the episode I think it will become clear as to why you should be concerned and I alluded to this a couple of times already but I want to be really clear that when people drink no matter who you are initially thereamp;#39;s that shutting down of those prefrontal cortical circuits now of course thereamp;#39;s going to be differences created by how quickly people are drinking whether or not theyamp;#39;re combining different types of alcohol the types of alcohol Etc but in general that can predict whether or not youamp;#39;re somebody who has a predisposition for alcoholism or not