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the doctor will then lubricate your rectum and gently insert the endoscope guiding it into your colon you may feel some pressure or tugging but you shouldnamp;#39;t feel pain to better examine abnormal looking tissues your doctor may choose to take one or more biopsies small instruments sent through the interior of the endoscope are able to painlessly remove small samples of tissue with a small scissor-like tool by simply snipping them free finally after a thorough exam the endoscope is carefully removed any tissue specimens removed during the procedure will be sent immediately to a lab for microscopic analysis your doctor will tell you when to expect results from those tests