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the nuclear pore complexes are the only channels through which small polar molecules ions and macromolecules can travel between the nucleus and the cytoplasm by controlling this traffic the nuclear pore complex plays a fundamental role in the physiology of all eukaryotic cells most proteins and RNAs are too large to move through the complex by passive diffusion and must move by an active process in which appropriate proteins and RNAs are recognized and selectively transported in a specific direction lets consider proteins imported from the cytoplasm to the nucleus only a subset of proteins can enter the nucleus and they are allowed in by virtue of having specific amino acid sequences called nuclear localization signals nuclear localization signals typically consist of one or two short segments of basic amino acids nuclear localization signals are recognized by nuclear transport receptors called importance which carry the cargo proteins into the nucleus with its cargo attached importan