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Welcome to 2 minute neuroscience, where I simplistically explain neuroscience topics in 2 minutes or less. In this installment I will discuss caffeine. Caffeine is a stimulant drug and the most widely-consumed mind-altering substance in the world. It belongs to a class of compounds known as the methylxanthines, and is commonly found in a number of natural sources including the seeds of coffee plants and the leaves of tea plants. Most of the effects of caffeine are thought to be traceable back to its action as an antagonist at receptors for a neurotransmitter called adenosine. This means that caffeine binds to adenosine receptors and blocks adenosine from binding there and activating the receptor; thus, it reduces activity at the adenosine receptor. Although there are 4 subtypes of the adenosine receptor, most of caffeines effects are thought to be due to its antagonistic actions at the A1 and A2A subtypes. Its ability to promote wakefulness may be especially due to actions at the a2a