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today letamp;#39;s discuss the mechanisms behind the pain relieving effects of opioids located in the brain and dorsal Horn of the spinal cord are opioid receptors that mediate the therapeutic analgesic effects and side-effects of opioid medications these receptors are located in many areas of the brain including the thalamus and in the periaqueductal grey and locus coeruleus that are origination for descending inhibitory pathways when these pathways are activated the signals descend to the spinal cord to inhibit ascending pain signals and prevent them from docHubing the brain opioids act as agonist at three main receptor types to exert their actions Mew receptors are responsible for the majority of opioid effects including but not limited to analgesia which is the pain relieving effect euphoria sedation respiratory depression and decreased peristalsis in the gut leading to constipation Delta receptors in the brain may have a hallucinogenic effect they are also located in the gut and c