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we load in a protein and extract the liquid by applying our selection on the green play button the binding cycle from the 6.5 amps through vicinity around the ligand is automatically defined in order to find proteins with similar binding sites we push the protein over into the protein editor mode here similar binding sites can be found for the external web server sienna by default 10 proteins with high sequence similarity will be loaded into csun already aligned with the query party up to 500 protein structures can be loaded in the query can be displayed as reference structure giving it a color code it can easily be compared to the hit structure in this 3d viewer the protein structure of interest can be added to the protein mode and used as receptor in all modes of seesaw