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all right lets go ahead and get started for today so in our previous lecture uh we spent time trying to explore the uh cell cytoskeleton and uh one of the functions of the status of the cytoskeleton is kind of serve as a track for a class of proteins called molecular Motors and well be talking about that today in the context of heart failure heart failure can be defined as when a persons heart cannot adequately pump enough blood to meet the bodys demand and that uh that problem can be kind of distilled down to a decreased contractility of the heart some of the symptoms that are associated with uh heart failure are dyspnea uh which we defined before as a shortness of breath or trouble breathing wheezing uh also edema edema can be defined as a fluid buildup uh its also characterized by fatigue nausea impaired thinking and interestingly increased heart rate the increased heart rate uh can largely be attributed to if you think back to the equation for uh cardiac output from your phys