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I want to give a summary of how you would terminate a the signal or the response of a g-protein coupled receptor and a g-protein based on if youre over firing and you want to desensitize this g-protein to some sort of extracellular ligand out here that keeps on binding and is over stimulating the g-protein coupled receptor and thus the internal signal and signaling cascade thats going on inside the cell so this is a video on the termination of of the response I guess of the response so we have seen that ligand binding results in receptor activation and the activated receptors will turn on some sort of g-protein right here and the G proteins turn on some sort of effectors so to prevent this over stimulation receptors need to be blocked from continuing to activate these G proteins the effector must be returned to their inactive state in other words so desensitization is the process that that blocks the active receptors from turning on additional G proteins and it takes place in two di