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lets look into more factors that affect how quickly the liver can clear drug from the body using the well-stirred model this time were going to look at protein binding now the equation is represented by F sub P in our analogy protein binding is determined by the number of barstools available many drug molecules to a greater or lesser extent bind to plasma proteins like albumin and alpha one as a glycoprotein when the drugs travel through the liver the drug molecules better bound to proteins arent metabolized its only the drug molecules that are floating around unbound that can be removed by the liver the bound drugs cant diffuse across the parasite membrane to docHub the liver enzymes that metabolize them for those drugs theyre highly protein bound hepatic clearance might change if something happens to the patient that reduces the amount of albumin in the blood less albumin means fewer places for the drug to bind and a higher reporting of drug unbound its as if we took away a bu
