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the first transcriptional regulators discovered in bacteria were found to have similar DNA binding regions there were two alpha helixes separated by a short term this is known as the helix-turn-helix motif and is only about 20 amino acids long all three domains of life bacteria archaea and eukaryotes utilize helix-turn-helix proteins in both general and specific transcription factors these are the most widespread transcription factors in prokaryotes and this domain has proven to be very versatile since it is incorporated into proteins that are involved in DNA replication Transpoamp;#39;s aces into graceamp;#39;s proteins involved in RNA metabolism and binding and even enzymes which can bind to proteins rather than nucleic acids the lactose repressor is NH th protein this regulates the activity of the lactose operon in transcribing the genes for lactose metabolism the repressor for the trip operon and bacteria is also an H th protein this operon controls the genes important for trypto
