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hi Iamp;#39;m dr. Zoe Walla animal lecturer in chemical biology the School of Pharmacy at UVA the aim of this video is to explain our recent research paper to a general audience it just been published in scientific reports the nature journal the paper itself is open access CERP solutely anyone else can read it the links to the paper included on the YouTube page title of the paper is mitoxantrone and unlocks bind and stabilize a motif forming DNA sequences the work is the result of the collaboration between the schools of pharmacy at UVA John in the center and the Institute of cancer therapeutics at Bradford so whatamp;#39;s the paper based on DNA is usually composed of four bases a T C and G DNA which is usually composed mainly of the bases G and C can actually form unusual DNA structures called G quadruplex s and I motifs these as you can see from the diagram look very different to the typical double helical structure which was first proposed by Watson and Crick in 1953 my group is