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when you look at the cells that make up an individual you see there are cells of all different shapes sizes structures and functions yet they all contain the same genome their DNA sequence is basically identical so how are there so many different cells when they have the same genomic DNA well this is in large part due to expression of different sets of genes in different cells the genome of an individual contains all the genes for that individual but only a specific subset of all these genes are used or expressed in different cells and there are many proteins in cells whose role it is to control the expression of other genes to make it possible to turn sets of genes on or off in different cell types these proteins are called transcription factors since they control the expression of the genes by regulating the process of gene transcription different cell types contain different combinations of transcription factors so that different sets of genes are transcribed depending on which tran