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DNA being wrapped around histones is what we refer to as a nucleosome and these nucleosomes decorate the DNA like beads on a string to package it in the nucleus it still is not clear how how transcription factors are able to bind these regions of DNA that are seamed wrapped up and hidden in this chromatin and then subsequently how can they open it so then itamp;#39;s like a new or itamp;#39;s an open region of DNA for James to be activated and expressed we know that it happens we just donamp;#39;t know how it happens and so we needed to use structure high resolution imaging in order to figure out how the interaction occurs between the transcription factor in specific transcription factors that we chose to look at I called opt for and Sox too they work together but they can or they have been referred to as pioneer transcription factors because they are the first vectors that are able to gain access to the DNA and nucleosomes and then open it up for other factors to come in li
