Bind motif in AMI

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Aug 6th, 2022
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How to bind motif in AMI

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the last part of mixed structures i want to show you are these these are alpha plus beta proteins that contain their binding dna and it turns out in particular the beta sheets are going to be really useful here because the beta sheet will expose the hydrogen bonds that can interact with the bases the first one this is called the so-called sink finger protein if you have lots of imagination you can think of this as a hand and then youamp;#39;re binding a sink here i said that you needed lots of imagination try to look it up online and i bet youamp;#39;re going to find a handy illustration somewhere this other protein is called a tata binding protein it has nothing to do with the indian consulting company tata this is a do you see again that is naturally twisting that had to do with the propensity of beta sheets to twist this twist has also evolved to fit perfectly in the major group of dna so what do you think that the tata binding protein does t a t a where have you seen those letter

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Transcription factor binding motifs (TFBMs) are genomic sequences that specifically bind to transcription factors. The consensus sequence of a TFBM is variable, and there are a number of possible bases at certain positions in the motif, whereas other positions have a fixed base.
A binding motif pair consists of two motifs each derived from one side of the binding protein sequences. The discovery is a directed approach that uses a combination of two data sources: 3-D structures of protein complexes and sequences of interacting proteins.
The Zinc Finger Motif The zinc finger DNA-binding motif is common to many transcription factors in the human genome.
Although each of these proteins has unique features, most bind to DNA as homodimers or heterodimers and recognize DNA through one of a small number of structural motifs. The common motifs include the helix-turn-helix, the homeodomain, the leucine zipper, the helix-loop-helix, and zinc fingers of several types.
Usually, interaction with the sugarphosphate backbone of the DNA molecules is nonsequence-specific. The helixturnhelix (HTH) motif is the most common motif found in DNA-binding proteins in both prokaryotes and eukaryotes.
The common motifs include the helix-turn-helix, the homeodomain, the leucine zipper, the helix-loop-helix, and zinc fingers of several types. The precise amino acid sequence that is folded into a motif determines the particular DNA sequence that is recognized.

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