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okay so welcome everyone today regulatory genomics motif discovery target prediction regulatory region dissection weamp;#39;re entering a new module weamp;#39;re going to talk about motifs today and then how to understand the networks and then some deep learning techniques in a couple of lectures so first weamp;#39;re going to talk about what are regulatory motifs then weamp;#39;re going to talk about two different ways of discovering them in co-regulated gene sets expectation maximization and deep sampling then weamp;#39;re going to talk about evolutionary signatures for the novo motif discovery and then weamp;#39;re going to talk about evolutionary signatures for individual instance identification and then weamp;#39;re going to talk about the novo dissection of regulatory regions using high throughput experiments so letamp;#39;s dive right in what are regulatory motifs so regulatory motifs are the building blocks of gene regulation so if you look at a region of gene regulatio