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all right so im really excited to have brian coventry uh with us tonight so uh brian did his phd with david baker at the university of washington in seattle and now hes a research scientist also for the ipd and brians work is focused on the one-sided de novo interface design problem so youve got a structure of the target you dont know what a binder should look like how can you design a protein that binds to a given site this has been something of a white whale for the protein design field i would say for a very long time now and um you know brian i would say has made a remarkable amount of progress in this more than the rest of the field combined and [Music] together with some other colleagues at ipd they just deposited a paper in pi archive which proposes a really the first general solution not a flag plant we did it once but as youll see today did it many times and so ill stop talking brian please take it away all right hello thank you uh lets try to share some screen all ri
