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Muscle contraction is at the basis of all skeletal movements. Skeletal muscles are composed of muscles fibers which in turn are made of repetitive functional units called sarcomeres. Each sarcomere contains many parallel, overlapping thin (actin) and thick (myosin) filaments. The muscle contracts when these filaments slide past each other, resulting in a shortening of the sarcomere and thus the muscle. This is known as the sliding filament theory. Cross-bridge cycling forms the molecular basis for this sliding movement. - Muscle contraction is initiated when muscle fibers are stimulated by a nerve impulse and calcium ions are released. - The troponin units on the actin myofilaments are bound by calcium ions. The binding displaces tropomyosin along the myofilaments, which in turn exposes the myosin binding sites. - At this stage, the head of each myosin unit is bound to an ADP and a phosphate molecule remaining from the previous muscular contraction. - The myosin heads release these pho