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In this 2-minute neuroscience tutorial, long-term potentiation (LTP) is explained as a process that strengthens synaptic connections between neurons with frequent activation. LTP is believed to be a mechanism for how the brain adapts to experiences, playing a crucial role in learning and memory. The most recognized mechanism of LTP involves the NMDA receptor, a type of glutamate receptor. Initially, glutamate activates the AMPA receptor. NMDA receptors nearby remain inactive due to a magnesium ion blocking their ion channel under low glutamate release. However, increased stimulation of AMPA receptors from frequent action potentials leads to depolarization of the postsynaptic neuron, facilitating LTP.