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Marina DiStefano, a clinical molecular genetics fellow at Harvard, introduces a three-part training series on transcript annotation and curation. Part 1 focuses on transcript annotation, discussing its importance with examples from the hearing loss clinical domain. An overview of transcript annotation bodies and their differences is provided. Gene curation is necessary for variant curation, as the effect of a variant on a gene cannot be determined if it is not associated with disease. Stay tuned for parts 2 and 3 for more on transcript curation resources and specific strategies in the hearing loss domain.