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In this lecture, payroll deduction is defined as amounts withheld from an employee's gross pay, also known as withholdings. The focus is primarily on payroll taxes, including federal income tax and FICA taxes, which encompass Social Security and Medicare. Additionally, deductions can be applied for benefits such as retirement and insurance plans. The process involves starting with the gross pay, which is the total amount earned by the employee. From this gross pay, various deductions such as FICA taxes and federal income tax are subtracted, ultimately affecting the take-home pay that employees actually receive.