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Marina DiStefano, a clinical molecular genetics fellow at Harvard, introduces a three-part training series on transcript annotation and curation. Part 1 focuses on why transcript curation is important, using examples from the hearing loss clinical domain. An overview of transcript annotation bodies and their differences is provided. Gene curation is necessary for variant curation, as the effect of a variant on a gene cannot be determined if the gene is not associated with disease. Part 2 discusses transcript curation resources, and part 3 covers a specific transcript curation strategy utilized in the hearing loss domain.