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In this video tutorial, the speaker discusses the process of obtaining letters of recommendation, emphasizing that it's a crucial yet daunting task. It’s recommended to secure 4 to 5 letters, including at least two from science professors, while maintaining flexibility for the other letters. Ideally, one letter should come from a non-science professor, while additional recommendations can be obtained from your research principal investigator (PI), a physician you've shadowed, and someone from a community or volunteer activity. The key takeaway is to request letters from individuals who know you well and to foster strong relationships with your letter writers, particularly your research PI.