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Marina DiStefano, a clinical molecular genetics fellow, presents a three-part series on transcript annotation and curation. Part 1 covers the importance of transcript curation in the context of hearing loss, as well as an overview of transcript annotation bodies. Gene curation is necessary for variant curation, as the impact of a variant on a gene depends on its association with disease. Check out parts 2 and 3 for more on curation resources and strategies in the hearing loss domain.