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Marina DiStefano, a clinical molecular genetics fellow at Harvard, discusses the importance of transcript annotation in the first part of a training series. She highlights the relevance of transcript curation in the hearing loss domain and outlines the series' content. Gene curation is essential for variant curation, as the effect of a variant on a gene can only be determined if the gene is associated with a disease. Part 2 and 3 will delve deeper into transcript curation resources and strategies used in the hearing loss domain.