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Ketamine was originally developed as an anesthetic and is now also used as an analgesic and antidepressant. It has been used recreationally since the 1970s. After administration, ketamine is quickly metabolized into an active metabolite called norketamine, which contributes to its anesthetic and analgesic effects. Both ketamine and norketamine function as antagonists at the NMDA receptor, which is responsible for glutamate neurotransmission. This inhibition of NMDA receptors significantly impacts neurotransmission, playing a crucial role in the anesthetic and analgesic properties of ketamine. Unlike traditional antidepressants that may take weeks to work, ketamine can start alleviating depressive symptoms within hours.