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Health Technology Assessments (HTAs) are systematic evaluations of the clinical, economic, and social implications of healthcare technologies, influencing decisions on their adoption and use. These technologies include drugs, medical devices, and diagnostic tests. HTAs review evidence regarding safety, efficacy, and cost-effectiveness, while also considering patient outcomes, ethical and social implications, and the feasibility of implementation in healthcare settings. Various stakeholders, such as policymakers, healthcare providers, and patients, utilize HTAs to guide informed decision-making regarding healthcare technologies. This tutorial is sponsored by Nested Knowledge, a platform for systematic literature reviews and meta-analysis.