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In this video, we discuss NMDA (N-methyl D-aspartate) receptors, a type of ionotropic glutamate receptor found at glutamatergic synapses. These ligand-gated ion channels regulate synaptic strength and plasticity, playing a crucial role in memory formation. NMDA receptors have unique properties and functions that are examined in detail. A key feature is the presence of magnesium ions in the receptor pore, which prevents sodium ions from entering when glutamate binds. The magnesium block is removed when there is a significant positive charge inside the membrane, allowing sodium ions to enter. The video also poses questions about the mechanisms responsible for removing the magnesium block.
