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Spending on health is limited by budget constraints, meaning that when new medicines are introduced, existing services must be adjusted or cut to accommodate the costs, known as opportunity cost. To ensure fair and consistent decision-making, UK authorities utilize health technology assessment (HTA). HTA evaluates medical, social, economic, and ethical aspects of a health technology—defined as any medicine, product, intervention, or service aimed at improving health—and assesses both its short- and long-term impacts. This process seeks to systematically and transparently compare the costs of the health technology with the benefits it provides to patient care, aiming for an unbiased and robust evaluation.