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great thank you so much so i am the one of the id pharmacists over at the va and when i was putting this together um my goal was to kind of simplify this because we have a lot of second year fellows who are going to be out practicing in the world on their own relatively soon so i wanted to simplify this as much as possible but its also the concepts are also applicable to our first years as well so um today what were going to do is were going to just review some pharmacokinetic parameters and then were really going to focus in on how to dose and monitor patients for when we use aminoglycoside so both extended interval and conventional and then iv vancomycin so well just start with the pk overview so uh this is a concentration versus time curve um which youre probably familiar with so essentially when you give a dose of a medication it starts to get absorbed um and then when the infusion ends itll distribute into the serum and the body tissues so you can see a couple of terms on y