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thatamp;#39;s um can you tell me a little bit more about how and when you consider the use of hypomethylated the vast majority of MDS patients at some point during their treatment course will have received these agents so again this is a sighted Dean or decided being again we know one way I like to tell patients for how it works it sort of turns on genes that have gone to sleep to kind of kill these cancer cells from within the ASA siding is most commonly given as an injection on either a five-day schedule for lower risk patients or a seven-day schedule for high-risk patients meaning five days in a row or seven days in a row it is okay to skip the weekend if needed which is often done in the community and this is given on monthly cycles as far as side-effects that we commonly see patients can have bruising or what we call hematomas in their belly or wherever the injections are given if those are very prominent we do have the ability to change those to an IV injection other tha