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the a randomized trial model is designed to address research questions that have yes or no answers in other words binary questions sometimes research questions in real life also have yes or no answers but such situations are in a minority more commonly we have to adapt the research question we are interested in to make it into a yes or no question in order to allow use of the randomized trial model as an example consider the question what is the effect of aspirin on the risk of having a heart attack this question potentially has a complex answer aspirin reduces the risk of heart attack by a quantifier amount and this varies depending on the risk factors in clinical condition of an individual patient in order to conduct a randomized trial we have to derive from this complex situation a yes or no question it is likely to be of the form in this group of patients does aspirin reduce the incidence of heart attack by more than 10% this process of casting a research issue as a yes or no quest