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welcome back to drug talk everybody in todayamp;#39;s video I want to quickly go over three things that you should know before taking Zoloft or Sertraline the first thing that people should be aware of when taking a medication like Zoloft is that it can take some time to docHub maximum effect as the rule of thumb you should notice some benefit within the first one to two weeks however it could take up to four to six weeks and sometimes even longer to realize the maximum benefit so for this reason itamp;#39;s important not to give up on this medication in the first couple weeks of therapy itamp;#39;s really important to get to that one or two month Mark before you conclude whether or not itamp;#39;s the right medication for you the second thing is that people should be aware that this medication has 12 off label indications off label prescribed is when a medication is used for an illness or disease other than the authorized reason for use some examples of the off-label indications th