Adapt index in PAP

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Aug 6th, 2022
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How to adapt index in PAP

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welcome back to kenton and habiba welcome today i thought i would bring you some medical information that is important and pertinent as we stand today so this video was recorded actually several months ago but i thought that it just did not seem appropriate in terms of the timing it was recorded right before the pandemic became you know an issue or became a major concern here in the united states and so i waited because i did not want to encourage people obviously to go see their doctor for non-uh emergent reasons now that things have settled into a new normal so to speak i thought that since you are now able most of us to either speak to a provider or see a provider it would be important to share this information so iamp;#39;m hoping you get something out of it get your pen and paper ready obviously the biggest thing on our mind lately is covid but we really should not also forget our general health and thereamp;#39;s so many things besides covid that you really should be concerned

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The tRNA Adaptation Index (tAI) is a measure of translational efficiency which takes into account the intracellular concentration of tRNA molecules and the efficiencies of each codonanticodon pairing (dos Reis et al., 2004).
The CAI is a measure of the synonymous codon usage bias for a DNA or RNA sequence and quantifies codon usage similarities between a gene and a reference set. The index ranges from 0 to 1, being 1 if a gene always uses the most frequently used synonymous codons in the reference set.
The method for estimating an expected CAI is based on generating 500 random sequences with the same amino acid composition as the query but with codon usage assigned randomly, either on the basis of the average G+C content of the input, or on the basis of the G+C percentage introduced by the user.
The CAI of a gene is simply defined as the geometric mean of the weight associated to each codon over the length (L) of the gene sequence (measured in codons).
Tyrosine: the mRNA codon is UAC and the tRNA anticodon is AUG.

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