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I wanted to talk today about why are dose constraints from the more well-known modality external beam radiotherapy not directly transferable to radiopharmaceutical therapy um because itamp;#39;s I think an important um question um so um pardon me um so as an outline Iamp;#39;d first like to start by introducing um what it comes down to is differences in dose distributions between rpt and ebrt or external radiotherapy which kind of Drive differences in the radiobiology which is uh my area of current research interest and so I thought Iamp;#39;d start by giving an overview of kind of the basics of external beam radiobiology and then so that if we understand that we can understand how rpt radiobiology is different and that will kind of segue into giving an understanding of some of the research that Iamp;#39;ve been working on over the past few years on trying to understand the connections and the similarities and the unique features of rpt radiobiology both the biological effective do