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This webcast is the fifth in a series focused on evidence-informed public health. It covers the steps of defining the problem, searching literature, critically appraising information, and synthesizing data to assess relevance for specific populations. The current session discusses adaptation based on research quality and relevance. Consideration of additional factors is essential for deciding whether to implement or discontinue an intervention. The presenters introduce an "Applicability and Transferability Tool," available on their website, alongside a supporting paper. This tool provides a systematic approach to evaluate interventions, including a one-page guide for practical application.