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This webcast is the fifth in a series on evidence-informed public health. It covers the process of defining problems, searching literature, critically appraising information, and synthesizing findings to assess relevance to specific populations. The focus now shifts to adaptation—considering additional factors in decision-making regarding the implementation or cessation of an intervention once research is deemed relevant. A tool for assessing applicability and transferability has been developed and is available on their website, along with a paper detailing its systematic literature review foundation. The tool includes a one-page process to guide practical application for each intervention under consideration.