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This webcast is the fifth in a series focused on evidence-informed public health. Previous topics covered include defining public health problems, searching literature, critically appraising information, and synthesizing relevant data. The current discussion focuses on adaptation, highlighting how to decide on using or discontinuing an intervention based on its relevance to a specific population. A key resource introduced is the applicability and transferability tool, available on their website, which assists in assessing interventions. Accompanying this tool is a paper detailing its development through a systematic literature review, along with a one-page process to aid in its practical application for various interventions.