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This webcast is the fifth in a series on evidence-informed public health. Previous sessions covered problem definition, literature searching, critical appraisal, and synthesizing information to assess its relevance to specific populations. The current focus is on adaptation—all factors influencing the decision to implement or discontinue an intervention after determining that research is both good quality and relevant. A new resource, the Applicability and Transferability Tool, has been developed and is available on the website, accompanied by a paper detailing its systematic development. The tool includes a one-page guide for practical application for each intervention under consideration.