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Age-related macular degeneration is a leading cause of adult blindness worldwide. This chronic progressive disease affects the part of the eye known as the macula. In a healthy eye, the choriocapillaris supplies oxygen and nutrients to the outer retina, which then pass through Bruchs membrane into the retinal pigment epithelium cells. These nutrients are vital to healthy function of the photoreceptors. Vitamin A is one of these nutrients. RPE cells convert vitamin A to 11-cis retinal, which moves from the RPE cell into the rod to be used for rhodopsin regeneration. Normal rhodopsin regeneration is required for normal rod-mediated dark adaptation function and thus normal night vision. In AMD, the RPE cells become damaged leading to the secretion of cholesterol, which becomes ubiquitous across the macula. The basal linear deposits form within Bruchs membrane while the basal laminar deposits form between Bruchs membrane and the RPE cells. These deposits contain the same type of cholest
