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High density lipoprotein is usually divided into three major subclasses. Nascent, discoidal or pre-1HDL comprises predominantly apo A-I and phospholipid. It is the preferred substrate for the ATP binding cassette transporter A1 (ABCA1), which actively exports free cholesterol from peripheral cells and macrophages.
LDL (Low-Density Lipoprotein) refers to unhealthy cholesterol and HDL (High-Density Lipoprotein) refers to healthy cholesterol.
There are two main types of cholesterol: low-density lipoprotein (LDL), or bad cholesterol, and high-density lipoprotein (HDL), or good cholesterol. Too much LDL cholesterol in your blood increases your risk for coronary artery disease and other heart diseases.
Answer From Francisco Lopez-Jimenez, M.D. For predicting your risk of heart disease, many healthcare professionals now believe that determining your non-HDL cholesterol level may be more useful than calculating your cholesterol ratio.
Based on the types of lipid abnormalities, dyslipidemias can be categorized into high total cholesterol (TC), High low-density lipoprotein cholesterol (LDL-C), High non-high-density lipoprotein cholesterol (non-HDL-C), High triglycerides (TG), and Low high-density lipoprotein cholesterol (HDL-C).
LDL and HDL have different purposes: LDL stands for low-density lipoproteins. It is sometimes called the bad cholesterol because a high LDL level leads to a buildup of cholesterol in your arteries. HDL stands for high-density lipoproteins.
Your HDL (good cholesterol) is the one number you want to be high (ideally above 60). Your LDL (bad cholesterol) should be below 100. Your total should be below 200. Talk with your provider about what your results mean for you and how to manage your cholesterol.
The IDL are further metabolized to LDL, which are taken up by the LDL receptor in numerous tissues including the liver, the predominant site of uptake. Reverse cholesterol transport begins with the formation of nascent HDL by the liver and intestine.