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[♪ INTRO] Its safe to say that general anesthesia has made modern medicine possible. So it might surprise you to hear that even though doctors have been using general anesthesia for nearly 200 years, they havent known exactly how it works in the brain to temporarily shut it down. We know that anesthesia doesnt just put someone to sleep. Its closer to a temporary coma, where you dont respond to pain or other stimuli. Your anesthesiologist can keep you in that state, and reverse it when its time to wake up. But whats actually happening in your brain while that goes on has been a mystery until now. There have been two main hypotheses for how anesthesia works on a molecular level. The first, called the lipid hypothesis, has been around since the turn of the 20th century. Thats when scientists observed that the potency of some anesthetics directly correlates with their ability to dissolve in oils. Our cell membranes are made of oily molecules called lipids. And there are several