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In America, the blood industry is a multibillion-dollar market, valued at $3.3 billion in 2021, contributing over 2% to U.S. exports. With no substitute for human blood, the demand often surpasses supply, resulting in one-day inventory levels and sporadic shortages that can affect lives. The FDA's blood donation policies, particularly a ban on donations from gay men, face criticism for not aligning with scientific evidence. Major companies like Grifols, CSL Plasma, Takeda's BioLife, and Octapharma dominate blood collection, especially plasma, often compensating donors. This plasma serves therapeutic purposes through large pharmaceutical firms, highlighting the complex dynamics in blood donation and collection.