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Syphilis, like the Black Death and smallpox, has earned its place in history as a burden on mankind. Syphilis gained its notoriety for its horrifying three stages, and caused its victims to go insane - a symptom that famously afflicted Friedrich Nietzsche and Al Capone. With advances in immunology, syphilis no longer poses a threat, and is easily treated. Worldwide, theres 6 million syphilis cases reported every year, and most are cured with a simple prescription of penicillin. However, its worth knowing something about a disease that ravaged Europe for 500 years, caused gruesome disfigurations, and made its victims go insane. This is the Dark Science of syphilis. [intro music] Syphilis was first recorded in mid-15th century Europe. It was most common among prostitutes and johns, making the afflicted associated with immorality and shame. It spread to North America in the late-15th century by European navigators who were exploring the New World. Syphilis is caused by the bacterium Tre