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Historically, many medical treatments appear barbaric due to a limited understanding of the human body. Diseases were often attributed to evil spirits or bad luck, leading to harmful practices. One notable example is treponation, a procedure where a hole is drilled into the skull to expose the brain, believed to cure various ailments. Evidence of treponation dates back to Neolithic times, found in cave paintings and ancient burial sites. Those seen as behaving abnormally were subjected to this practice, which was thought to release evil spirits. Additionally, treponation was employed as a general treatment for conditions like seizures and epilepsy.