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The NMDA receptor, along with the AMPA receptor, is a key glutamate receptor, often found together at synapses, such as in the CA1 region of the hippocampus. When a presynaptic neuron is weakly stimulated, it releases glutamate, which binds to both receptors. However, under weak stimulation, only AMPA receptors are typically activated, leading to slight depolarization of the postsynaptic neuron. NMDA receptors, when activated at slightly depolarized voltages, allow minimal ion flow due to a magnesium ion blockage in the channel's pore, preventing free movement of ions. This distinction in receptor activation plays a crucial role in synaptic signaling.

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