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welcome to basic sciences todays topic is surgical margins in tumor resection firstly one must draw the cross-section of a limb around the central tumor is a reactive zone comprising compressed normal tissues inflammatory cells and small numbers of tumor cells tumors tend to stay within osteo facial anatomical compartments intralesional is when the reception passes through tumor marginal is when the resection passes through the reactive zone wide local excision is when the resection passes through normal tissue radical excision is when the whole of the involved compartment is removed