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Motor neuron disease (MND), also known as amyotrophic lateral sclerosis (ALS), is a group of neurological disorders that impact motor neurons in the brain and spinal cord. The causes remain unclear, but factors such as genetics, age, lifestyle, environmental influences, and neuroinflammation are thought to play a role. Prognosis varies based on disease type, progression, age of onset, and overall health. While there is currently no cure, risk reduction measures include regular exercise, avoiding toxins, maintaining a healthy diet, quitting smoking, and getting sufficient sleep. Ongoing research is exploring gene therapy, stem cell therapy, neuroprotective drugs, and assistive technology.