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welcome everyone this is another episode of the live scientist fans podcast Iamp;#39;m very excited for this episode Iamp;#39;m Omar and of course thatamp;#39;s Jonathan we uh co-run a group together at MIT focused on molecular technology development for Gene cell therapy and Beyond itamp;#39;s the ability to take a place in genome and insert into that place specifically a very large piece of sequence so we say large we mean that in the sense of letter and weamp;#39;re talking on the order of 100 to a thousand or even 10 000 letters into the genome with technology such as Pace being able to insert now large pieces of of genes with few amounts of Underside deletions or or insertions and thatamp;#39;s going to be a very interesting technology which is going to pave the way for interesting applications there are seven thousand genetic diseases but thereamp;#39;s actually like millions of variants for example cystic fibrosis has 1800 different mutations cystic fibrosis is an area th