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understanding addiction the science behind substance dependence addiction is a complex and often misunderstood issue that affects millions of people worldwide it is a chronic disease that alters the brainamp;#39;s reward system leading to Compulsive substance used despite negative consequences this article will explore the science behind addiction including how it develops and its effects on the brain and behavior what is addiction addiction is a chronic disease characterized by compulsive substance used despite negative consequences it affects the brainamp;#39;s reward system leading to changes in Behavior thoughts and emotions addiction is often associated with substance abuse but it can also involve behaviors such as gambling or overeating how does addiction develop addiction develops over time as the brainamp;#39;s reward system is hijacked by the pleasurable effects of substance use when a person uses drugs or alcohol the brain releases dopamine a neurotransmitter that produces